In her position as Medical Director, Cardiology and Neurovascular at Synarc, she is responsible for the scientific oversight of all cardiovascular projects including coordination and collaboration with key opinion leaders and expert readers as well as our Sponsor’s scientific counterparts. Dr. Ziola participates in clinical trial protocol design and data interpretation and regulatory strategy planning. She oversees the quality of Synarc’s cardiology and neurovascular reading services and explores new applications of imaging to clinical trial research.

Dr. Ziola has more than twenty years of cardiovascular experience in support of pharmaceutical research and development programs. Her expertise includes clinical analysis, interpretation, and reporting of cardiac safety data for over 100 clinical trials in various therapeutic indications, including cardiovascular, infectious disease, oncology, CNS, gastroenterology, and endocrinology.

Dr. Ziola holds her medical degree from the Nicolaus Copernicus Jagiellonian University Medical School in Krakow, Poland. She has participated in expert meetings, given invited lectures and co-authored several scientific articles.

Prior to joining Synarc, Dr. Ziola worked at ARYx Therapeutics leading global cardiovascular clinical trials design, conduct and monitoring. Earlier in her career, she served as Director of Cardiovascular Clinical Services position at Gentiae Clinical Research, a cardiovascular core lab she helped establish, supporting central reading of cardiac imaging and electrocardiography. Prior to that she was affiliated with the groundbreaking Ischemia Research and Education Foundation.

Dr. Margaret Ziola can be reached by phone at +1.415.817.7975 and email at margaret.ziola@synarc.com.

 
 

Scientific Publications / Presentations:

Michael Ezekowitz, Rangadham Nagarakanti, Stefan Hohnloser, Andrzej Lubinski, Olga Bandman, Daniel Canafax, David J Ellis, Peter G Milner, Margaret Ziola, Bernard Thibault: “Time Dependent Efficacy of Budiodarone, an Analog of Amiodarone, in Patients with Paroxysmal AF and Implantable Pacemaker Capable of Monitoring Rhythm”. Circulation 2009;120:S692.
     
Stefan H. Hohnloser,  Andrzej Lubinski, Olga Bandman, Daniel Canafax, David J. Ellis, Peter G. Milner, Margaret Ziola, and Bernard Thibault: “PASCAL: A Randomized, Double-Blind, Placebo-Controlled Study of Budiodarone (ATI-2042) in Patients with Paroxysmal Atrial Fibrillation and Pacemakers with Atrial Fibrillation Data Logging Capabilities” .Presented at Heart and Rhythm Society Meeting in Boston, May, 2009.

The Multicenter Study of Perioperative Ischemia McSPI Research Group—Europe and the San Francisco Analysis Team: Perioperative Sympatholysis: Effects of Alpha2-adrenoceptor Agonist, Mivazerol on Hemodynamic Stability, Myocardial Ischemia and Adverse Events Anesthesiology 1997 Feb;86 (2):346-63
Jain U, Laflamme C, Aggarwal A, Ramsey J, Comunale M, Ghoshal S, Ngo L, Ziola K, Hollenberg M, Mangano DT, McSPI Research Group: “Electrocardiographic and Hemodynamic Changes and their Association  with Myocardial Infarction During Coronary Artery Bypass Surgery:  A Multicenter Study.”  Anesthesiology 86:576-591, 1997.

Wahr JA, Plunkett JJ, Ramsey JG, Reeves J, Jain U, Ley C, Wilson R, Mangano DT, McSPI Research Group: “Cardiovascular Responses During Sedation After Coronary Revascularization.” Anesthesiology 84: 1350-60, June 1996

Jain U, Body SC, Bellows W, Wolman R, Mora Mangano CT, Mathew J, Youngs EA, Mangano DT, McSPI Research Group: “Multicenter Study of Target -controlled Infusion of Propofol-Sufentanil or Sufentanil-Midazolam for Coronary Artery Bypass Graft Surgery.”  Anesthesiology 85 (3):522-535, 1996.

Leung JM, Stanley T, Mathew M, Curling P, Barash P, Salmenpera M, Reeves J, Hollenberg M, and Mangano D, for the SPI Research Group (see Appendix): “An Initial Multicenter, Randomized Controlled Trial on the Safety and Efficacy of Acadesine in Patients Undergoing Coronary Artery Bypass Graft Surgery.”  Anesth Analg 78:420-34, 1994.

Helman JD, Leung JM, Bellows WH, Pineda N, Roach GW, Reeves JD, Howse J, McEnany MT, Mangano DT, the SPI Research Group:  “The Risk of Myocardial Ischemia in Patients Receiving Desflurane versus Sufentanil Anesthesia for Coronary Artery Bypass Graft Surgery.” Anesthesiology 77:47-62, 1992.

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